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J105 3D Chemical Imager

The J105 3D Chemical Imager s a high performance SIMS system which uses DC primary
cluster beams and a revolutionary time of flight analyser to create a new paradigm
in organic analysis. The use of a DC primary ion beam allows rapid imaging with
continuous data acquisition (i.e. no separate etch cycle), with simultaneous high
spatial resolution and high mass resolution. For imaging of organic samples,
the instrument is equipped with 40 kV C60 and gold cluster beams.
The analyser is a dual-focussing combination of a shaped field buncher and a non-linear reflectron.

Automated sample insertion, a 1 micron precision 3-axis stage and camera assisted
sample positioning allow simple and precise experimental setup. There is also
provision for cold sample handling and fracture to facilitate analysis of frozen hydrated
or freeze-dried samples. The J105 operates entirely under computer control;
experiments can be routinely pre-programmed and run automatically.


• High mass resolution and high spatial resolution at the same time.
• Depth profiling
• 3D imaging
• Large area imaging
• Rapid, continuous acquisition
• Automated operation
• Advanced data viewing facility

The following data, provided by the Surface Anaysis and Research Centre at The
University of Manchester, illustrates the versatility and performance of the J105
Instrument in tissue and cell analysis
Imaging of cheek cells

The image to the left shows m/z 102.8 concentrated in the cell nuclei, and mass 103.0
throughout the cell, demonstrating the need for high mass resolution when imaging.
The field of view was approximately 170 x 150 microns.
Imaging of unwashed rat kidney section

By using a stage scanning programme, a series of small area images can be tiled to
form a large area image. The data shown above were acquired by tiling 10 x 10
images, each 32 x 32 pixels, to form a total image with FOV 9 x 9 mm.
The images show the different distributions in the kidney of m/z 184 (left) and
577 (right).
3D cell imaging

3D reconstruction of image data from benign prostatic hyperplasia (BPH) cells.
Iso-surface rendering shows the distribution of signal in 3D through the entire sample
while orthogonal slices through the data set facilitate visualisation of the chemical
distribution within cells.

MS-MS of Haloperidol

When the MS-MS mode is selected on the
J105, gas is introduced into a collision cell
just before the first time focus, and an ion
gate on the time focus selects the parent
mass of interest. The figure shows the
MS-MS spectrum of Haloperido;
showing parent peak and daughter peaks
from collision induced dissociation.